In conditions like Chronic kidney disease, symptoms usually develop gradually and may include:
Swelling in the hands, feet, or face (edema)
Fatigue
Changes in urination
Foamy urine (protein in urine)
High blood pressure
Nausea or loss of appetite
Notice that prominent veins are not on this list.
The Role of Fluid Balance
Kidneys play a key role in fluid regulation. When they aren’t functioning properly, the body may retain fluid. This usually causes puffiness or swelling, not more visible veins.